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. Author manuscript; available in PMC: 2016 Feb 18.
Published in final edited form as: Adv Healthc Mater. 2014 Oct 21;4(3):460–468. doi: 10.1002/adhm.201400421

Figure 1.

Figure 1

(A) Schematic representation of the preparation of GNSs with a diamond core. First, a silica shell is created on diamond particles, followed by formation of a GNS upon reduction of [AuCl4]− promoted by adsorbed gold nanoparticle seeds. The GNS is modified with a lipoic acid-PEG conjugate, which is terminated with an alkyne. Using click chemistry, Alexa Fluor 647 dye and azide-modified transferrin (the targeting protein) are attached in consecutive steps. (B–D) TEM microphotographs of (B) diamond particles, (C) silica-coated diamond particles (ND@Sil), (D) silica-coated diamond particles with gold seeds, and (E) GNSs a with diamond core (ND@Au). The magnification is the same for all microphotographs, and the scale bar corresponds to 100 nm.