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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Clin Cancer Res. 2014 Oct 27;21(9):2020–2028. doi: 10.1158/1078-0432.CCR-14-0586

Table 5.

Multivariate analyses of risk factors for overall mortality among patients who were alive and disease free at one year after HCT

number RR Odds Ratio p-value
Presence of cGVHD
No cGVHD 3936 1.00
cGVHD 3547 1.56 1.41 1.73 <0.0001
Acute GVHD History <0.0001
none 4051 1.00
aGVHD in first 29 days 2446 1.11 0.93 1.24 0.0716
aGVHD after day 29 986 1.46 1.28 1.67 <0.0001
Disease <0.0001
AML 2541 1.00
ALL 1798 1.26 1.10 1.45 0.0008
CML 2498 0.73 0.64 0.83 <0.0001
MDS 652 0.84 0.70 1.00 0.0521
Disease Status at HCT <0.0001
Early 4661 1.00
Intermediate 1823 1.25 1.10 1.41 <0.0001
Advanced 999 1.83 1.59 2.11 0.0005
HLA match 0.0191
Sibling Donor 1861 1.00
Well Matched Unrelated 1412 1.18 1.03 1.36 0.0199
Partially matched Unrelated 1369 1.12 0.92 1.29 0.1148
Poorly matched Unrelated 841 1.26 1.07 1.49 0.0049
TBI in the conditioning regimen
no 3186 1.00
yes 4292 1.20 1.07 1.34 0.0015
Sex match <0.0001
Donor male/recipient male 2662 1.00
Donor male/recipient female 1720 0.94 0.83 1.08 0.3982
Donor female/recipient male 1629 1.43 1.27 1.62 <0.0001
Donor female/recipient female 1472 1.03 0.90 1.18 0.7114
Graft Source
Bone marrow 5354 1.00
Mobilized blood stem cells 2129 1.24 1.10 1.40 0.0004

Factors tested, but not listed in table: Recipient age, sex, donor parity, donor-recipient CMV serology, use of ATG, GVHD prophylaxis, aGVHD grade, year of transplant, platelet count at cGVHD diagnosis, serum bilirubin at cGVHD diagnosis, type of cGVHD onset, KPS/L at cGVHD diagnosis, severity of cGVHD at 1 year post-transplant, organ involvement of cGVHD at 1 year post-transplant