Table 5.
Multivariate analyses of risk factors for overall mortality among patients who were alive and disease free at one year after HCT
| number | RR | Odds Ratio | p-value | ||
|---|---|---|---|---|---|
| Presence of cGVHD | |||||
| No cGVHD | 3936 | 1.00 | |||
| cGVHD | 3547 | 1.56 | 1.41 | 1.73 | <0.0001 |
| Acute GVHD History | <0.0001 | ||||
| none | 4051 | 1.00 | |||
| aGVHD in first 29 days | 2446 | 1.11 | 0.93 | 1.24 | 0.0716 |
| aGVHD after day 29 | 986 | 1.46 | 1.28 | 1.67 | <0.0001 |
| Disease | <0.0001 | ||||
| AML | 2541 | 1.00 | |||
| ALL | 1798 | 1.26 | 1.10 | 1.45 | 0.0008 |
| CML | 2498 | 0.73 | 0.64 | 0.83 | <0.0001 |
| MDS | 652 | 0.84 | 0.70 | 1.00 | 0.0521 |
| Disease Status at HCT | <0.0001 | ||||
| Early | 4661 | 1.00 | |||
| Intermediate | 1823 | 1.25 | 1.10 | 1.41 | <0.0001 |
| Advanced | 999 | 1.83 | 1.59 | 2.11 | 0.0005 |
| HLA match | 0.0191 | ||||
| Sibling Donor | 1861 | 1.00 | |||
| Well Matched Unrelated | 1412 | 1.18 | 1.03 | 1.36 | 0.0199 |
| Partially matched Unrelated | 1369 | 1.12 | 0.92 | 1.29 | 0.1148 |
| Poorly matched Unrelated | 841 | 1.26 | 1.07 | 1.49 | 0.0049 |
| TBI in the conditioning regimen | |||||
| no | 3186 | 1.00 | |||
| yes | 4292 | 1.20 | 1.07 | 1.34 | 0.0015 |
| Sex match | <0.0001 | ||||
| Donor male/recipient male | 2662 | 1.00 | |||
| Donor male/recipient female | 1720 | 0.94 | 0.83 | 1.08 | 0.3982 |
| Donor female/recipient male | 1629 | 1.43 | 1.27 | 1.62 | <0.0001 |
| Donor female/recipient female | 1472 | 1.03 | 0.90 | 1.18 | 0.7114 |
| Graft Source | |||||
| Bone marrow | 5354 | 1.00 | |||
| Mobilized blood stem cells | 2129 | 1.24 | 1.10 | 1.40 | 0.0004 |
Factors tested, but not listed in table: Recipient age, sex, donor parity, donor-recipient CMV serology, use of ATG, GVHD prophylaxis, aGVHD grade, year of transplant, platelet count at cGVHD diagnosis, serum bilirubin at cGVHD diagnosis, type of cGVHD onset, KPS/L at cGVHD diagnosis, severity of cGVHD at 1 year post-transplant, organ involvement of cGVHD at 1 year post-transplant