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. 2015 May;145(5):431–442. doi: 10.1085/jgp.201511354

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© 2015 Ufret-Vincenty et al.

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Figure 1. — Proposed PI(4,5)P₂-binding sites in TRPV1 and GIRK2. (A) Regions shown to be important for PI(4,5)P₂ regulation mapped onto the apo-state structure of TRPV1 (PDB ID: 3J5P). One of the four subunits is shown primarily in blue, with S6 in cyan, the helix following S6 in magenta, and the region following this helix shown in dark gray. The approximate position of R721 is indicated by the blue circle. The red circle represents a phosphoinositide head group. Likely membrane position is denoted by dashed lines. (B) Amino acids implicated in PI(4,5)P₂ modulation of GIRK2 channels, based on functional experiments, mapped onto the tetrameric Kir3.2 structure (PDB ID: 3SYA). Amino acids as discussed in Xie et al. (2007) are shown as ball and sticks colored in CPK. The assigned diC8-PI(4,5)P₂ from the structure is shown as cyan sticks.