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. 2015 Apr 20;6:6921. doi: 10.1038/ncomms7921

Figure 4. Intra-tumour MH decreases from diagnosis to relapse in DLBCL patients.

Figure 4

(a) Epipolymorphism levels are dependent on DNA methylation levels. All the loci were divided into different groups based on their methylation level and median epipolymorphism of each group is calculated. Genome-wide intra-tumour MH was quantified by area under the median line. (b) Median epipolymorphism lines for diagnosis and relapse tumors from patient 1.1 in our cohort. Intra-tumor MH visibly decreased with tumour evolution. (c) Relapsed samples displayed significant lower intra-tumour MH. Out of 13, 12 pairs displayed lower intra-tumour MH. All the loci were located in CGIs. (d) Relapsed samples displayed significant lower intra-tumour MH. All the loci located in gene promoter. Out of 13, 11 pairs displayed lower intra-tumour MH. In c,d, intra-tumour MH was measured by area under median epipolymorphism line in sample-by-sample manner. P values were obtained from paired t-test of intra-tumour MH between diagnosis and relapsed samples.