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Model of ternary CBP:TDG:RAR complex action The interaction of CBP with RA-activated RARα cooperates with the interactions of TDG with CBP and RARα in order to stabilize a ternary complex composed of all three molecules, which affects the expression of RA-dependent genes (top). The P65A mutant of TDG is still able to interact with RARα, but fails to bind CBP, resulting in the inability to form a stable functional ternary complex (bottom).
