Table 2.
The most relevant biological pathways identified in spinal muscular atrophy network
| Pathway | Pathway coverage | P value | Clique coefficient | Star coefficient | Path coefficient |
|---|---|---|---|---|---|
| AGE−RAGE pathway | 39/66 | 3.75E−12 | 0.0789 | 0.3051 | 6 |
| BDNF signaling pathway | 61/140 | 1.93E−10 | 0.0484 | 0.2602 | 6 |
| Prolactin signaling pathway | 40/76 | 2.74E−10 | 0.0814 | 0.2922 | 5 |
| Inhibition of cellular proliferation by Gleevec | 17/22 | 1.25E−08 | 0.136 | 0.3417 | 4 |
| Leptin signaling pathway | 32/61 | 1.86E−08 | 0.1008 | 0.3742 | 5 |
| Androgen receptor | 59/148 | 2.22E−08 | 0.0649 | 0.6289 | 4 |
| ATF-2 transcription factor network | 31/61 | 8.13E−08 | 0.0753 | 0.3471 | 5 |
| Glucocorticoid receptor regulatory network | 37/80 | 1.11E−07 | 0.0691 | 0.3675 | 4 |
| MAPK signaling pathway | 61/161 | 1.16E−07 | 0.0522 | 0.2562 | 5 |
| Chronic myeloid leukemia | 34/73 | 2.94E−07 | 0.066 | 0.3163 | 5 |
| mRNA processing | 50/126 | 3.07E−07 | 0.0861 | 0.3142 | 5 |
| Striated muscle contraction | 22/38 | 3.26E−07 | 0.0736 | 0.3905 | 6 |
| ErbB2/ErbB3 signaling events | 23/42 | 6.89E−07 | 0.1206 | 0.3658 | 4 |