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. 2015 Apr 14;2015:403291. doi: 10.1155/2015/403291

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Copyright © 2015 Sachin L. Badole et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of PPSB-PEE on histopathology of heart in rats. A-group I: nondiabetic, B-group II: diabetic control (tween 80, 2%; 10 mL/kg, p.o.), and C-group III: PPSB-PEE (100 mg/kg, p.o.). (a) Nondiabetic rat showing normal architecture of heart (Grade − −). (b) Diabetic control rat heart showing massive necrosis of heart muscle fibers along with focal mass and fragmentation (+++). (c) PPSB-PEE (100 mg/kg, p.o.) treated rat heart showing minimum pathological changes, that is, swelling of myocardial fibers and focal degeneration (++). Grade −: no injury; Grade ++++: severe injury; Grade ++: moderate injury (magnification 10x).