. Author manuscript; available in PMC: 2015 Apr 28.

Published in final edited form as: Clin Liver Dis. 2014 Aug;18(3):561–574. doi: 10.1016/j.cld.2014.05.004

Table 2.

Definitions of renal dysfunction in patients with cirrhosis.

	Hepatorenal Syndrome	Acute Kidney Injury Network	IAC & ADQI
Cirrhosis required	Yes	Yes	Yes
Absence of underlying renal disease	Required	Not required	Not required, Acute on chronic kidney disease defined
Minimum serum Creatinine	≥1.5	Stage 2 & 3 yes, serum creatinine ≥1.5	No
Stages/Types	Yes	Yes	No
Criteria	1) ascites, 2) no improvement after 2 days of diruetic w/drawal & volume expansion, 3) no shock, 4) no nephrotoxic drugs; Type 1: Doubleing in serum creatinine to ≥2.5 in <14 days	Stage 1= ≥0.3 mg/dL in <48 hrs or increase 1.5-2 × baseline	AKI: ≥0.3 mg/dL in <48 hrs or >50% over baseline
		Stage 2 = increase 2-3 × baseline	AKI: ≥0.3 mg/dL in <48 hrs or >50% over baseline
		Stage 3 = increase >3 × baseline or >4.0 mg/dL with an acute ≥0.5mg/dL increase	CRD: estimated GFR < 60 mL/min for > 3 months by MDRD6

IAC, International Ascites Club; ADQI, Adult Dialysis Quality Initiative, AKI, acute kindney injury; CRD, chronic renal disease; MDRD6, Modification of Diet in Renal Disease 6 formula