Fig. 4.
Iso-induced injury in WT and RGS-insensitive Gαi2G184S/G184S mice. Mice were injected with saline or isoproterenol (30 mg/kg) daily for 7 days then tissues collected, weighed, and processed for microscopy as described in “Methods.” a HW/BW after saline or Iso treatment in WT and RGS-insensitive Gαi2G184S/G184S mice. b Images of transverse myocardial sections. c Myocyte cross sectional area measured using NIH-Image as described in “Methods.” Values are mean±SEM, n =6–8 for HW/BW and >250 for myocyte size in each group. *p<0.05 or ***p<0.001 for Iso- vs saline-treated animals or †††p<0.001 for WT vs Gαi2G184S/G184Sby ANOVA