Table 4.

Structural comparison of regional volume and cortical thickness measurements between the nine former NFL players (NFL) and nine elderly healthy control (EHC) participants who also underwent [¹¹C]DPA-713 PET.

	NFL, mean (SD)	EHC, mean (SD)	P
Brain region volume (mm3)
Right hippocampus	3493.0 (440.4)	4232.4 (392.0)	0.002**
Left hippocampus	3526.8 (476.7)	4174.5 (447.3)	0.009*
Right amygdala	1799.0 (349.3)	2111.1 (340.8)	0.073
Left amygdala	1556.9 (241.3)	1832.9 (87.5)	0.009*
Total gray matter	556,785.8 (34,890.2)	591,657.7 (41,901.4)	0.074
Brain parenchymal volume	1,058,862.9 (55,241.4)	1,112,091.9 (79,279.2)	0.120
Brain region cortical thickness (mm)
Right parahippocampal CTX	2.42 (0.30)	2.73 (0.40)	0.07
Left parahippocampal CTX	2.51 (0.32)	2.66 (0.38)	0.41
Right entorhinal CTX	3.29 (0.38)	3.36 (0.41)	0.72
Left entorhinal CTX	3.13 (0.27)	3.14(0.31)	0.95
Right temporal pole	3.40 (0.31)	3.66 (0.49)	0.19
Left temporal pole	3.45 (0.41)	3.50 (0.25)	0.75
Right supramarginal gyrus	2.22 (0.13)	2.33 (0.19)	0.19
Left supramarginal gyrus	2.27 (0.18)	2.36 (0.16)	0.27

^*P < 0.05.

^**P < 0.0036, indicating a significant difference after correction for multiple testing.