Table 5.
Preclinical studies using other pox vectors as vaccine candidates against different viral, bacterial and parasitic infectious diseases.
| Pox Strain | Target Pathogen or Disease | Heterologous Antigen | Status | References |
|---|---|---|---|---|
| Raccoon poxvirus | Influenza A | HA and NA from H5N1 | preclinical | [191] |
| Bubonic plague | F1 capsular antigen of Yersinia pestis | preclinical | [192,193,194,195,196] | |
| Rabies | Glycoprotein | preclinical | [19,197,198,199,200] | |
| Internal structural NP | preclinical | [198,201] | ||
| Feline panleukopenia | VP2 | preclinical | [199,202] | |
| FIPV | Nucleocapsid | preclinical | [203] | |
| Parapoxvirus (orf) | Influenza A | HA or NP from H5N1 | preclinical | [204] |
| Rabies | Glycoprotein | preclinical | [205] | |
| PRV | Glycoproteins gC and/or gD | preclinical | [206,207,208] | |
| Borna disease | NP p40 | preclinical | [209] | |
| RVHD | VP1 (VP60) | preclinical | [210] | |
| CSFV | E2 glycoprotein | preclinical | [211] | |
| Capripoxvirus | PPRV | F or HA | preclinical | [212,213,214,215,216,217,218] |
| HIV/AIDS | HIV-1 subtype C Gag, reverse transcriptase, Tat and Nef | preclinical | [219,220] | |
| Rift Valley fever | Glycoproteins Gn and Gc | preclinical | [221,222] | |
| Rinderpest | F or HA | preclinical | [223,224,225,226,227] | |
| Bluetongue | VP2, VP7, NS1 and NS3 | preclinical | [228,229] | |
| Rabies | Glycoprotein | preclinical | [230] | |
| Suipoxvirus | PCV2-associated disease | IL-18 + Cap, Cap | preclinical | [231,232] |
| SEZ | M-like protein (SzP) | preclinical | [232] | |
| MRP of S. suis type 2 (SS2) | preclinical | [233] | ||
| Swine influenza | HA1 from H3N2 and H1N1 | preclinical | [234,235] | |
| HA1 from H3N2 | preclinical | [236] | ||
| HA1 from H1N1 | preclinical | [236] | ||
| Myxomavirus | Bluetongue | VP2 | preclinical | [237] |
| Feline calicivirus disease | Cap | preclinical | [238,239] | |
| Influenza | HA from H5N1 | preclinical | [240,241] | |
| RVHD | Capsid protein (VP60) | preclinical | [242,243,244,245] |
Abbreviations: HA: Hemagglutinin; NA: Neuraminidase; NP: Nucleoprotein; FIPV: Feline infectious peritonitis virus; F: Fusion protein; PCV2: Porcine circovirus type 2; Cap: Capsid protein; MRP: Muramidase-related protein; PRV: Pseudorabies virus; PPRV: Peste des petits ruminants virus; CSFV: Classical swine fever virus; SEV: Streptococcus equi ssp. Zooepidemicus; RVHD: Rabbit Viral Hemorrhagic Disease.