Table 2.
Meta-analysis of miR-146a rs2910164 polymorphism with gastric cancer by population
| Population | Comparison | No. of study | Test of association | Test of heterogeneity | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | P (Q-test) | I 2 | |||
| Asian | GG vs. CC | 7 | 1.016(0.780, 1.324) | 0.906 | 0.000 | 75.2% |
| CG vs. CC | 0.998(0.847, 1.176) | 0.982 | 0.014 | 62.2% | ||
| CG/GG vs. CC | 1.005(0.830, 1.216) | 0.962 | 0.001 | 75.1% | ||
| GG vs. CG/CC | 1.025(0.861, 1.221) | 0.779 | 0.036 | 55.6% | ||
| G vs. C | 1.006(0.877, 1.153) | 0.935 | 0.000 | 78.7% | ||
| European | GG vs. CC | 2 | 1.331(0.802, 2.210) | 0.269 | 0.512 | 0.0% |
| CG vs. CC | 0.880(0.619, 1.253) | 0.478 | 0.973 | 0.0% | ||
| CG/GG vs. CC | 0.994(0.716, 1.380) | 0.971 | 0.875 | 0.0% | ||
| GG vs. CG/CC | 1.326(0.995, 1.767) | 0.054 | 0.512 | 0.0% | ||
| G vs. C | 1.146(0.937, 1.401) | 0.184 | 0.608 | 0.0% | ||
| Overall | GG vs. CC | 9 | 1.056(0.836, 1.334) | 0.649 | 0.001 | 68.1% |
| CG vs. CC | 0.984(0.853, 1.136) | 0.830 | 0.037 | 51.3% | ||
| CG/GG vs. CC | 1.005(0.852, 1.184) | 0.956 | 0.002 | 66.9% | ||
| GG vs. CG/CC | 1.076(0.925, 1.251) | 0.342 | 0.052 | 48.0% | ||
| G vs. C | 1.028(0.914, 1.155) | 0.648 | 0.000 | 72.5% | ||