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. 2015 Mar 1;16:7. doi: 10.1186/s12868-015-0145-7

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© Franco-Pérez et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of chloroquine and mefloquine on the generalized seizures induced by pentylenetetrazole and maximal electroshock. A) Chloroquine (CRQ) did not protect against the generalized tonic-clonic seizures (GTCS) induced by pentylenetetrazole (PTZ). The level of significance (*p < 0.05) was determined by independent Fisher’s exact probability test comparing each experimental group versus control vehicle group. Vehicle + PTZ (n = 8), MFQ 40 mg/kg + PTZ (n = 8), CRQ 40 mg/kg + PTZ (n = 8). B) CRQ did not modify the incidence of tonic hindlimb extension (THLE) induced by maximal electroshock (MES). However, this drug decreased the duration of THLE but in minor proportion that a similar dose of mefloquine. The level of significance (*p < 0.05) was determined by nonparametric Kruskal-Wallis analysis followed by Dunnet test. Vehicle (n = 6), MFQ 40 mg/kg (n = 6), CRQ 40 mg/kg (n = 6).