Table 1.
Age of onset in years, adjusted HR analysis for overall survival rates in patients with pemphigus vulgaris
| Characteristic | No (%) | Deaths | HR (95% CI) | p-value |
|---|---|---|---|---|
| No (%) | ||||
| Age of onset ≥ 65 years | 27 (25.0%) | 12 (70.6%) | 9.37 (95%CI 3.3 – 26.65) | <0.001 |
| Age of onset < 65 years | 81 (75.0%) | 5 (29.4%) | ||
| Gender (M) | 46 (42.6%) | 6 (35.3%) | 0.73 (0.26 – 2.09) | 0.561 |
| Gender (F) | 62 (57.4%) | 11 (64.7%) | ||
| Ethnicity (Romanian) | 100 (92.6%) | 16 (94.1%) | 0.57 (0.07 – 4.12) | 0.588 |
| Ethnicity (Roma) | 8 (7.4%) | 1 (5.9%) | ||
| Alcohol consumption (Yes) | 20 (18.5%) | 3 (17.7%) | 1.52 (0.42 – 5.51) | 0.524 |
| Alcohol consumption (No) | 88 (81.5%) | 14 (82.3%) | ||
| Smoking (Yes) | 29 (26.9%) | 2 (11.8%) | 1.36 (0.29 – 6.33) | 0.698 |
| Smoking (No) | 79 (73.1%) | 15 (88.2%) | ||
| Subtype of PV | ||||
| Mucocutaneous | 80 (74.1%) | 14 (82.3%) | 2.60 (0.34 – 19.93) | 0.357 |
| Cutaneous | 13 (12.0%) | 1 (5.9%) | ||
| Mucous | 15 (13.9%) | 2 (11.8%) | 1.72 (0.16 – 18.97) | 0.659 |
| High blood pressure (Yes) | 28 (25.9%) | 6 (35.3%) | 0.95 (0.35 – 2.60) | 0.928 |
| High blood pressure (No) | 80 (74.1%) | 11 (64.7%) | ||
| Coronary heart disease (Yes) | 11 (10.2%) | 5 (29.4%) | 3.04 (1.07 – 8.67) | 0.037 |
| Coronary heart disease (No) | 97 (89.8%) | 12 (70.6%) | ||
| Heart failure (Yes) | 4 (3.7%) | 1 (5.9%) | 0.63 (0.08 – 4.76) | 0.651 |
| Heart failure (No) | 104 (96.3%) | 16 (94.1%) | ||
| Cardiac arrhythmia (Yes) | 5 (4.6%) | 3 (17.7%) | 2.70 (0.75 – 9.59) | 0.125 |
| Cardiac arrhythmia (No) | 103 (95.4%) | 14 (82.3%) | ||
| Diabetes mellitus (Yes) | 8 (7.4%) | 2 (11.8%) | 0.91 (0.21 – 3.99) | 0.898 |
| Diabetes mellitus (No) | 100 (92.6%) | 15 (88.2%) | ||
| Stroke (Yes) | 5 (4.6%) | 1 (5.9%) | 1.08 (0.14 – 8.22) | 0.944 |
| Stroke (No) | 103 (95.4%) | 16 (94.1%) | ||
| Depression (Yes) | 5 (4.6%) | 1 (5.9%) | 2.09 (0.27 – 16.22) | 0.480 |
| Depression (No) | 103 (95.4%) | 16 (94.1%) | ||
| Dental problems (Yes) | 57 (52.8%) | 7 (41.2%) | 0.85 (0.32 – 2.28) | 0.750 |
| Dental problems (No) | 51 (47.2%) | 10 (58.8%) | ||
| ESR ≥ 30 mm/hour | 26 (42.6%) | 9 (75.0%) | 1.51 (0.37 – 6.20) | 0.570 |
| ESR < 30 mm/hour | 35 (57.4%) | 3 (25.0%) | ||
| Steroids ≥ 1 mg/kg/day | 15 (15.0%) | 2 (14.3%) | 0.88 (0.19 – 4.05) | 0.868 |
| Steroids < 1 mg/kg/day | 85 (85.0%) | 12 (85.7%) | ||
| Anti-Dsg1 autoAbs ≥ 100 U/mL | 45 (45.5%) | 11 (64.7%) | 1.98 (0.71 – 5.53) | 0.195 |
| Anti-Dsg1 autoAbs < 100 U/mL | 54 (54.5%) | 6 (35.3%) | ||
| Anti-Dsg3 autoAbs ≥ 100 U/mL | 71 (71.7%) | 11 (64.7%) | 0.60 (0.22 – 1.63) | 0.314 |
| Anti-Dsg3 autoAbs <100 U/mL | 28 (28.3%) | 6 (35.3%) |