Table 3.
Differences between survival rates at 1, 3, 5 and 10 years, in patients with pemphigus vulgaris
| Characteristic | Survival rate (%) | 3 | 5 | 10 | p-value |
|---|---|---|---|---|---|
| Follow up (years) 1 | |||||
| Age of onset ≥ 65 years | 72.2% | 67.4% | 48.4% | 41.5% | < 0.001 |
| Age of onset < 65 years | 97.3% | 97.3% | 91.4% | 91.4% | |
| Survival difference (%) | 25.1% | 29.9% | 43.0% | 49.9% | |
| Gender (M) | 88.0% | 88.0% | 83.6% | 83.6% | 0.611 |
| Gender (F) | 93.3% | 91.3% | 78.7% | 75.1% | |
| Survival difference (%) | 5.3% | 3.3% | 4.9% | 8.5% | |
| Ethnicity (Romanian) | 90.6% | 89.3% | 81.1% | 79.0% | 0.816 |
| Ethnicity (Roma) | 100.0% | 100.0% | 75.0% | 75.0% | |
| Survival difference (%) | 9.4% | 10.7% | 6.1% | 4.0% | |
| Alcohol consumption (Yes) | 83.3% | 83.3% | 83.3% | 83.3% | 0.997 |
| Alcohol consumption (No) | 92.8% | 91.4% | 80.1% | 77.5% | |
| Survival difference (%) | 9.5% | 8.1% | 3.2% | 5.8% | |
| Smoking (Yes) | 92.1% | 92.1% | 92.1% | 92.1% | 0.299 |
| Smoking (No) | 90.9% | 89.4% | 78.1% | 75.6% | |
| Survival difference (%) | 1.2% | 2.7% | 14.0% | 16.5% | |
| Subtype of PV | |||||
| Mucocutaneous | 90.8% | 89.2% | 76.8% | 76.8% | 0.692 |
| Cutaneous | 92.3% | 92.3% | 92.3% | 92.3% | |
| Mucous | 92.9% | 92.9% | 92.9% | 79.6% | |
| High blood pressure (Yes) | 88.5% | 83.6% | 77.2 % | 70.7 % | 0.303 |
| High blood pressure (No) | 92.0% | 92.0% | 81.8% | 81.8% | |
| Survival difference (%) | 3.5% | 8.4% | 4.6% | 11.1% | |
| Coronary heart disease (Yes) | 70.7% | 70.7% | 58.9% | 44.2% | 0.003 |
| Coronary heart disease (No) | 93.4% | 92.0% | 83.1% | 83.1% | |
| Survival difference (%) | 22.7% | 21.3% | 24.2% | 38.9% | |
| Heart failure (Yes) | NA | 100.0% | 100.0% | 0.0% | 0.697 |
| Heart failure (No) | 90.8% | 89.5% | 79.9% | 79.9% | |
| Survival difference (%) | NA | 10.5% | 20.1% | 79.9% | |
| Cardiac arrhythmia (Yes) | 53.3% | 53.3% | 53.3% | 26.7% | 0.001 |
| Cardiac arrhythmia (No) | 92.8% | 91.5% | 81.7% | 81.7% | |
| Survival difference (%) | 39.5% | 38.2% | 28.4% | 55.0% | |
| Diabetes mellitus (Yes) | 87.5% | 87.5% | 65.6% | 65.6% | |
| Diabetes mellitus (No) | 91.5% | 90.2% | 81.8% | 79.6% | |
| Survival difference (%) | 4.0% | 2.7% | 16.2% | 14.0% | 0.438 |
| Stroke (Yes) | 80.0% | 80.0% | 80.0% | 80.0% | 0.749 |
| Stroke (No) | 91.7% | 90.5% | 80.6% | 78.4% | |
| Survival difference (%) | 11.7% | 10.5% | 0.6% | 1.6% | |
| Depression (Yes) | 80.0% | 80.0% | 80.0 % | 80.0% | 0.629 |
| Depression (No) | 91.7% | 90.4% | 80.8% | 78.7% | |
| Survival difference (%) | 11.7% | 10.4% | 0.8% | 1.3% | |
| Dental problems (Yes) | 90.5% | 88.0% | 84.8% | 84.8% | 0.508 |
| Dental problems (No) | 91.9% | 91.9% | 77.2% | 73.6% | |
| Survival difference (%) | 1.4% | 3.9% | 7.6% | 11.2% | |
| ESR ≥ 30 mm/hour | 84.6% | 80.4% | 66.4% | 60.9% | 0.039 |
| ESR < 30 mm/hour | 93.6% | 93.6% | 88.9% | 88.9% | |
| Survival difference (%) | 9.0% | 13.2% | 22.5% | 28.0% | |
| Steroids ≥ 1 mg/kg/day | 93.3% | 93.3% | 84.9% | 84.8% | 0.726 |
| Steroids < 1 mg/kg/day | 93.6% | 92.0% | 81.0% | 78.1% | |
| Survival difference (%) | 0.3% | 1.3% | 3.9% | 6.7% | |
| Anti-Dsg1 autoAbs ≥ 100 U/mL | 84.2 % | 81.3% | 68.8% | 68.8% | 0.039 |
| Anti-Dsg1 autoAbs < 100 U/mL | 96.1 % | 96.1% | 88.3% | 84.9% | |
| Survival difference (%) | 11.9 % | 14.8% | 19.5 % | 16.1% | |
| Anti-Dsg3 auto Abs ≥ 100 U/mL | 91.3% | 89.5% | 80.4% | 80.4% | 0.506 |
| Anti-Dsg3 auto Abs < 100 U/mL | 89.3% | 89.3% | 78.8% | 71.6% | |
| Survival difference (%) | 2.0% | 0.2% | 1.6% | 8.8% |