Table 1.
Influence of chronic testosterone withdrawal on myocardial contractility
| Component | Model | Functional change | Duration of GDX (weeks) | Species | Reference |
|---|---|---|---|---|---|
| LVDP | Langendorff | ↔ | 2 | Rat | [75] |
| ↔ | 9 | Rat | [76] | ||
| a↓ | 16 | Rat | [74] | ||
| Working heart | b↓ | 3 | Rat | [77] | |
| b↓ | 10 | Rat | [78] | ||
| LVEDP | Millar catheterization | ↔ | 10–11 | Mouse | [69] |
| Langendorff | ↔ | 2 | Rat | [75] | |
| Working heart | b↓ | 3 | Rat | [77] | |
| b↓ | 10 | Rat | [78] | ||
| +dP/dT | Millar catheterization | ↔ | 10–11 | Mouse | [69] |
| Langendorff | ↔ | 9 | Rat | [76] | |
| a↓ | 16 | Rat | [74] | ||
| −dP/dT | Millar catheterization | ↔ | 10–11 | Mouse | [69] |
| Langendorff | ↔ | 9 | Rat | [76] | |
| a↓ | 16 | Rat | [74] | ||
| Working heart | b↓ | 3 | Rat | [77] | |
| b↓ | 10 | Rat | [78] |
aEffect of GDX is reversed by testosterone replacement. bFunctional change in the working heart model was only observed at high left atrial pressures.