Skip to main content
. 2014 Oct 4;15:103. doi: 10.1186/s12881-014-0103-8

Table 1.

Details of the genes and studies in this meta-analysis study

Gene SNP Article No. of studies Population Case definition T1D/T2D OR a
CCR5 (Chemokine Receptor 5) rs7637813 Pettigrew et al, [16] 1 Irish EDNb 1 1.173(0.932-1.478)
10577983 Pettigrew et al, [16] 1 1.163(0.935-1.447)
rs2227010 Pettigrew et al, [16] 1 1.0(0.805-1.248)
rs17765882 Pettigrew et al, [16] 1 1.501(0.980-2.298)
rs2734648 Tregouet et al, [17] 3 Danish EDN 1 0.969(0.788-1.191)
Tregouet et al, [17] Finnish EDN 1 1.186(0.947-1.486)
Tregouet et al, [17] French EDN 1 1.082(0.853-1.373)
Del 32/rs333 Ahluwalia et al, [18] 4 North Indian EDN 2 2.58 (1.98–3.37)
Ahluwalia et al, [18] South Indian EDN 2 0.88 (0.51–1.5)
Pettigrew et al, [16] Irish EDN 1 1.242(0.859-1.794)
Mlynarski et al, [19] American ADNc 1 0.959(0 .652 1.410)
59029 G.A/rs1799987 Pettigrew et al, [16] 10 Irish EDN 1 1.017(0.818-1.263)
Ahluwalia et al, [18] North Indian EDN 2 2.22 (1.71–2.87)
Ahluwalia et al, [18] South Indian EDN 2 2.17 (1.43–3.29)
Buraczynska et al, [20] Polish EDN 2 1.83(1.43-2.34)
Mlynarski et al, [19] American ADN 1 0.904(0.664- 1.23)
Nakajima et al, [21] Japanese EDN 2 1.179(0.855-1.627)
Tregouet et al, [17] Danish EDN 1 1.112(0.918-1.348)
Tregouet et al, [17] Finnish EDN 1 1.152(0.938-1.415)
Tregouet et al, [17] French EDN 1 1.063(0.845-1.336)
Prasad et al, [22] Indian ADN 2 1.379(1.047-1.818)
ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) rs266729 Zhang et al, [23] 2 European EDN + ADN 1 1.120(0.929-1.35)
Wu et al, [24] Taiwanese EDN 2 1.39(1.0-1.9)
rs17300539 Vionnet et al, [25] 4 Danish EDN and Retd 1 1.348(0.965-1.884)
Vionnet et al, [25] Finnish EDN and Ret 1 1(0.570-1.754)
Vionnet et al, [25] French EDN and Ret 1 1.472(0.998-2.171)
Prior et al, [26] British EDN and Ret 1 1.924 (1.024-3.617)
IL8 (Interleukin-8) rs4073 Ahluwalia et al, [18] 2 North Indian EDN 2 1.44 (1.1–1.88)
Ahluwalia et al, [18] South Indian EDN 2 1.5 (0.96–2.33)
CCL2 (Chemokine ligand 2) rs1024611 Ahluwalia et al, [18] 2 North Indian EDN 2 1.04 (0.8–1.36)
Joo et al, [27] Korean ADN 2 0.91(0.65-1.2)
rs3917887 Ahluwalia et al, [18] 2 North Indian EDN 2 2.03 (1.57–2.63)
Ahluwalia et al, [18] South Indian EDN 2 1.7 (1.12–2.57)
MMP9 (Matrix Metallopeptidase 9) rs17576 Ahluwalia et al, [18] 2 North Indian EDN 2 1.81 (1.40–2.34)
Ahluwalia et al, [18] South Indian EDN 2 2.19 (2.45–3.31)
IL-10 (Interleukin-10) –592C/A/rs1800872 Arababadi et al, [28] 2 Iranian EDN 2 1.484(0.944-2.331)
Ezzidi et al, [2]/ Mtiraoui et al, [29] Tunisian EDN 2 0.915(0.751-1.114)
–819C/T/rs1800871 Ezzidi et al, [2]/ Mtiraoui et al, [29] 1 0.777(0.631-0.958)
–1082G/A/rs1800896 Ezzidi et al, [2]/ Mtiraoui et al, [29] 1 0.841(0.694-1.018)
IL-1 (Interleukin-1) IL1A Loughrey et al, [30] 1 Caucasian EDN 1 0.66 (0.42-1.04)
IL1B Loughrey et al, [30] 1 1.971(1.221-3.182)
IL1RI Loughrey et al, [30] 1 0.94(0.618-1.429)
VEGFA (Vascular endothelial growth factor A) - 2549 I/D/rs35569394 Yang et al, [31] 2 British EDN and Ret 1 1.619(1.038-2.525)
Buraczynska et al, [32] Polish EDN 2 1.09(0.77-1.54)
+405/rs2010963 Buraczynska et al, [32] 2 Polish EDN 2 0.949(0.658-1.369)
McKnight et al, [33] Irish EDN and Ret 1 0.88 (0.69-1.12)
-1499C > T/rs833061 McKnight et al, [33] 2 Irish EDN and Ret 1 2.08(1.63-2.66)
-2578C > A/rs699947 McKnight et al, [33] 2 Irish EDN and Ret 1 0.92(0.72-1.17)
rs2146323 Tregouet et al, [17] 3 Danish EDN 1 0.899(0.732-1.105)
Tregouet et al, [17] Finnish EDN 1 0.914(0.739-1.131)
Tregouet et al, [17] French EDN 1 0.854(0.667-1.095)
rs3024997 Tregouet et al, [17] 3 Danish EDN 1 0.967(0.786-1.191)
Tregouet et al, [17] Finnish EDN 1 0.986(0.773-1.257)
Tregouet et al, [17] French EDN 1 1.124(0.879-1.438)
rs3025000 Tregouet et al, [17] 3 Danish EDN 1 0.962(0.781-1.186)
Tregouet et al, [17] Finnish EDN 1 0.974(0.765-1.240)
Tregouet et al, [17] French EDN 1 1.087(0.843-1.402)
936C/T/rs3025039 Kim et al, [34] 2 korean EDN + ADN 2 1.632(0.984-2.708)
VEGFB (Vascular endothelial growth factor B) rs12366035 Tregouet et al, [17] 3 Danish EDN 1 0.784(0.633-0.971)
Tregouet et al, [17] Finnish EDN 1 0.92(0.727-1.163)
Tregouet et al, [17] French EDN 1 1.144(0.887-1.474)
VEGFC (Vascular endothelial growth factor C) rs585706 Tregouet et al, [17] 3 Danish EDN 1 0.8(0.562-1.139)
Tregouet et al, [17] Finnish EDN 1 1.318(0.917-1.895)
Tregouet et al, [17] French EDN 1 1.271(0.882-1.832)
IL-6 (Interleukin-6) rs2069827 Ng et al, [35] 1 Caucasian EDN + ADN 2 0.65(0.365-1.159)
rs1800796 Ng et al, [35] 0.935(0.588-1.487)
rs1800795 Ng et al, [35] 0.829(0.623-1.104)
rs2069837 Ng et al, [35] 0.865(0.54-1.384)
rs2069840 Ng et al, [35] 0.916(0.686-1.225)
rs2069861 Ng et al, [35] 1.505(0.882-2.569)
TGF-B1 (Transforming growth factor beta 1) rs1800470 Jahromi et al, [36] 8 Caucasian EDN 1 1.06(0.64-1.7)
Ahluwalia et al, [18] North Indian EDN 2 1.1 (0.83–1.44)
Ng et al, [37] Caucasian EDN + ADN 1 0.923(0.722–1.180)
McKnight et al, [33] Irish EDN 1 1.2(0.7-2.1)
Tregouet et al, [17] Danish EDN 1 0.979(0.799-1.199)
Tregouet et al, [17] Finnish EDN 1 1.068(0.852-1.338)
Tregouet et al, [17] French EDN 1 1.034(0.816-1.311)
Salgado et al, [38] Mexican EDN + ADN 2 1.30(0.99-1.71)
Tyr81His/rs111033611 Ahluwalia et al, [18] 1 North Indian EDN 2 1.14 (0.53–2.46)
915 G > C/rs1800471 Ng et al, [37] 3 Caucasian EDN + ADN 2 1.022(0.627–1.665)
McKnight et al, [33] Irish EDN 1 1.0(0.66-1.5)
Salgado et al, [38] Mexican EDN + ADN 2 4.17(1.40-12.3)
-800 A > Grs1800468 Ng et al, [37] 4 Caucasian EDN + ADN 2 1.178(0.762–1.821)
McKnight et al, [33] Irish EDN 1 0.75(0.45-1.2)
Prasad et al, [22] Indian ADN 2 1.04(0.816-1.325)
Salgado et al, [38] Mexican EDN + ADN 2 0.98(0.46-2.09)
rs1800469 Ng et al, [37] 3 Caucasian EDN + ADN 2 1.088(0.841–1.407)
McKnight et al, [33] Irish EDN 1 0.94(0.58-1.5)
Prasad et al, [22] Indian ADN 2 0.738(0.50-1.091)
rs1800472 Ng et al, [37] 1 Caucasian EDN + ADN 2 1.168(0.639–2.135)
rs2241717 Tregouet et al, [17] 3 Danish EDN 1 0.957(0.787-1.164)
Tregouet et al, [17] Finnish EDN 1 1.068(0.864-1.322)
Tregouet et al, [17] French EDN 1 0.917(0.729-1.155)
rs8179181 Tregouet et al, [17] 3 Danish EDN 1 1.193(0.957-1.488)
Tregouet et al, [17] Finnish EDN 1 1.022(0.799-1.308)
Tregouet et al, [17] French EDN 1 0.944(0.722-1.234)
TGF-BR1 (TGF beta receptor 1) rs1571589 Tregouet et al, [17] 3 Danish EDN 1 0.951(0.746-1.213)
Tregouet et al, [17] Finnish EDN 1 1.111(0.836-1.476)
Tregouet et al, [17] French EDN 1 1.018(0.766-1.352)
rs928180 Tregouet et al, [17] 3 Danish EDN 1 1.362(0.988-1.877)
Tregouet et al, [17] Finnish EDN 1 0.92(0.67-1.263)
Tregouet et al, [17] French EDN 1 0.901(0.608-1.334)
TGF-BR2 (TGF beta receptor 2) 747C > G/rs11466531 McKnight et al, [33] 1 Irish EDN 1 1.37(1.0-1.89)
1149G > A/ss50394788 McKnight et al, [33] 1 Irish EDN 1 2.432(0.81-7.303)
CCR2 (chemokine receptor type 2) G46295A/rs1799864 Joo et al, [27] korean ADN 2 0.91(0.65-1.2)
rs1799865 Prasad et al, [22] 1 Indian ADN 2 1.551(0.901-2.671)
RANTES/CCL5 (Chemokine ligand 5) C-28G/rs2280788 Joo et al, [27] 2 korean ADN 2 0.97(0.65-1.4)
Nakajima et al, [21] Japanese EDN 2 1.532(1.004-2.338)
ss161639200 Pettigrew et al, [16] 1 irish EDN 1 1.140(0.821-1.584)
rs9898132 Pettigrew et al, [16] 1 Irish EDN 1 1.092(0.746-1.599)
G-403A/rs2107538 Joo et al, [27] 3 Korean ADN 2 0.8(0.59-1.0)
Pettigrew et al, [16] Irish EDN 1 1.085(0.81-1.452)
Nakajima et al, [21] Japanese EDN 2 0.88(0.632-1.225)
EPO (Erythropoietin) rs1617640 Tong et al, [39] 3 American EDN + ADN 2 1.446(1.145-1.826)
Tong et al, [39] 1 1.535(1.320-1.787)
Tong et al, [39] 1 1.382(1.050-1.820)
TNFα (Tumor necrosis factor) -308/rs1800629 Prasad et al, [22] 1 Indian ADN 2 1.383(0.775-2.468)

aOR, Odds ratio (95% CI); bEDN, established diabetic nephropathy; cADN, advanced diabetic nephropathy; dRet, retinopathy.

This meta- analysis included 55 SNPs in 18 genes of inflammatory cytokines and angiogenesis which were associated with diabetic nephropathy.