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IC 50 and maximum non-cytotoxic concentration to normal cells established for the five pre-selected compounds (4 m, 4bt (dimethylenastron), 4p, 4bc and 4x) and monastrol
| Compound | IC50(μM) | Maximum non-cytotoxic concentration to normal cells (mM) | |
|---|---|---|---|
| MCF-7 | MDA-MB-231 | ||
| 4 m | 197.3 | 77.08 | 1.0 |
| 4bt | 126.9 | 17.91 | 0.8 |
| 4p | 87.5 | 68.38 | 0.4 |
| 4bc | 234.9 | 249.5 | 1.0 |
| 4x | 276.5 | 237.4 | 0.8 |
| Monastrol | 110.4 | 113.9 | 1.0 |
These concentrations were determined based on cells treatment for 72 h.
