Table 2.
Meta-analysis for the hsa-miR-499 rs3746444 T > C polymorphism and cancer risk
| Genetic model | N a | C vs T | TC vs TT | CC vs TT | TC/CC vs TT (dominant) | CC vs TC/TT (recessive) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pooled OR [95% CI] | P h b | P c | Pooled OR [95% CI] | P h b | P c | Pooled OR [95% CI] | P h b | P c | Pooled OR [95% CI] | P h b | P c | Pooled OR [95% CI] | P h b | P c | ||
| Total | 31 | 1.08 (0.99-1.17) | <0.00001 | 0.08 | 1.11 (1.00-1.23) | <0.00001 | 0.04 | 1.02 (0.85-1.22) | 0.002 | 0.85 | 1.11 (1.01-1.23) | <0.00001 | 0.03 | 0.98 (0.81-1.17) | 0.001 | 0.79 |
| Ethnicities | ||||||||||||||||
| Asian | 28 | 1.10 (1.00-1.21) | <0.00001 | 0.06 | 1.14 (1.02-1.27) | <0.00001 | 0.02 | 1.02 (0.82-1.27) | 0.0009 | 0.86 | 1.14 (1.02-1.27) | <0.00001 | 0.02 | 0.97 (0.78-1.20) | 0.0004 | 0.76 |
| Chinese | 16 | 1.11 (0.95-1.28) | <0.00001 | 0.18 | 1.18 (1.02-1.35) | 0.0002 | 0.02 | 0.92 (0.65-1.32) | 0.001 | 0.66 | 1.15 (0.99--1.34) | <0.00001 | 0.07 | 0.89 (0.63-1.24) | 0.004 | 0.48 |
| Indian | 4 | 1.03 (0.87-1.23) | 0.19 | 0.70 | 1.26 (0.84-1.88) | 0.005 | 0.26 | 0.91 (0.63-1.31) | 0.33 | 0.62 | 1.18 (0.84-1.65) | 0.02 | 0.34 | 0.79 (0.52-1.20) | 0.18 | 0.27 |
| Korean | 3 | 0.94 (0.78-1.13) | 0.26 | 0.49 | 0.89 (0.72-1.11) | 0.27 | 0.31 | 0.89 (0.54-1.48) | 0.62 | 0.66 | 0.93 (0.75-1.15) | 0.25 | 0.48 | 0.95 (0.58-1.57) | 0.65 | 0.84 |
| Iranians | 2 | 1.57 (1.23-2.01) | 0.34 | 0.0003 | 0.99 (0.68-1.45) | 0.54 | 0.97 | 2.23 (1.42-3.51) | 0.54 | 0.0005 | 1.38 (1.00-1.91) | 0.78 | 0.05 | 2.23 (1.44-3.45) | 0.41 | 0.0003 |
| Others | 3 | 1.11 (0.96-1.29) | 0.88 | 0.16 | 1.22 (0.77-1.95) | 0.04 | 0.40 | 1.24 (0.89-1.73) | 0.67 | 0.20 | 1.19 (0.86-1.63) | 0.16 | 0.30 | 1.13 (0.77-1.67) | 0.21 | 0.53 |
| Caucasian | 3 | 0.95 (0.88-1.04) | 0.39 | 0.28 | 0.93 (0.77-1.12) | 0.12 | 0.44 | 0.96 (0.76-1.20) | 0.97 | 0.71 | 0.93 (0.80-1.09) | 0.19 | 0.36 | 0.98 (0.78-1.22) | 0.87 | 0.83 |
| Cancer type | ||||||||||||||||
| Liver cancer | 8 | 1.12 (0.85-1.54) | <0.00001 | 0.46 | 1.14 (0.85-1.54) | 0.0002 | 0.38 | 1.03 (0.55-1.92) | 0.0005 | 0.93 | 1.15 (0.82-1.61) | <0.00001 | 0.43 | 0.99 (0.57-1.71) | 0.002 | 0.97 |
| Breast cancer | 4 | 1.25 (0.99-1.57) | 0.0002 | 0.06 | 1.15 (0.91-1.45) | 0.04 | 0.24 | 1.43 (0.87-2.34) | 0.009 | 0.16 | 1.24 (0.99-1.55) | 0.03 | 0.06 | 1.30 (0.75-2.24) | 0.002 | 0.35 |
| Gastric cancer | 4 | 1.03 (0.90-1.18) | 0.49 | 0.66 | 0.98 (0.83-1.15) | 0.54 | 0.79 | 1.21 (0.84-1.75) | 0.66 | 0.31 | 1.01 (0.86-1.17) | 0.53 | 0.95 | 1.22 (0.85-1.76) | 0.66 | 0.28 |
| Colorectal cancer | 3 | 0.96 (0.82-1.13) | 0.42 | 0.62 | 1.05 (0.87-1.26) | 0.96 | 0.64 | 0.61 (0.23-1.62) | 0.09 | 0.32 | 1.00 (0.84-1.20) | 0.73 | 0.99 | 0.61 (0.23-1.58) | 0.10 | 0.31 |
| Lung cancer | 2 | 0.96 (0.82-1.13) | 0.83 | 0.64 | 0.98 (0.81-1.18) | 0.60 | 0.84 | 0.88 (0.54-1.44) | 0.92 | 0.61 | 0.97 (0.81-1.16) | 0.68 | 0.74 | 0.87 (0.54-1.42) | 0.84 | 0.59 |
| Esophageal cancer | 2 | 0.80 (0.66-0.98) | 0.75 | 0.03 | 0.81 (0.63-1.04) | 0.80 | 0.10 | 0.60 (0.33-1.08) | 0.88 | 0.09 | 0.79 (0.62-1.00) | 0.83 | 0.05 | 0.64 (0.36-1.14) | 0.93 | 0.13 |
| Others | 8 | 1.11 (0.97-1.26) | 0.05 | 0.13 | 1.27 (0.98-1.65) | <0.0001 | 0.07 | 0.99 (0.79-1.25) | 0.80 | 0.93 | 1.12 (0.98-1.53) | 0.0004 | 0.07 | 0.91 (0.72-1.16) | 0.37 | 0.46 |
aNumber of comparisons.
bP h value of Q-test for heterogeneity test. Random-effects model was used when P value for heterogeneity test <0.1; otherwise, fix-effects model was used.
cP value for significance, the cutoff point of statistical significance was set at p < 0.05, which was shown in boldface.