Table 2.
Pfcrt haplotypes and frequency of Pfmdr1 codons in Nigerian children
| Gene | n | Genotype/haplotype | Prevalence (%) |
|---|---|---|---|
| Pfcrt | 119 | CVIET (mutant type) | 109 (91.6) |
| Amino acids (72–76) | CVMNK (wild type) | 5 (4.2) | |
| CVMNK/CVIET (mixed) | 5 (4.2) | ||
| Pfmdr1 | |||
| Amino acids 86, 184, 1034, 1042 and 1246 | 74 | 86Y (mutant type) | 46 (62.2) |
| 86 N (wild type) | 14 (18.9) | ||
| 86 N + 86Y (mixed) | 14 (18.9) | ||
| 71 | 184 F (mutant type) | 49 (69) | |
| 184Y (wild type) | 11 (15.5) | ||
| 184 F + 184Y (mixed) | 11 (15.5) | ||
| 81 | 1034C (mutant type) | 0(0) | |
| 1034S (wild type) | 81(100) | ||
| 81 | 1042D (mutant type) | 0(0) | |
| 1042 N (wild type) | 81(100) | ||
| 29 | 1246S (mutant type) | 0(0) | |
| 1246D (wild type) | 29(100) |