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. 2015 Apr 1;16:109. doi: 10.1186/s12859-015-0536-x

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© Khuri and Wuchty; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Enrichment of interactions within and between protein complexes. (A) Schematic illustration of interactions that appear between and within complexes. In (B) we determined the number of interactions between MDSet, essential or e-MDSet proteins in the same complex as well as within complexes in E. coli, S. cerevisiae and H. sapiens. As a random null model, we resampled proteins in complexes 10,000 times. Generally, we found that interactions between complexes appear diluted while interactions in the same complexes seemed to be enriched. While they appeared significant in sets of interactions between essential proteins we observed that such signals were enhanced in interaction sets between e-MDSet proteins (P < 10⁻⁴).