Table 3.
Most significantly differentially expressed genes of HDF cells after incubation with PAH and L=PAH Au NPsa
| Gene Symbol | Entrez ID | Gene name | Isoelectric Pointb | Fold Change | |
|---|---|---|---|---|---|
| PAH Au NPs | L-PAH Au NPs | ||||
| KRTAP2-3 | 730755 | keratin associated protein 2–3 | 7.62 | 3.62 | 4.39 |
| CXCL1 | 2919 | chemokine (C-X-C motif) ligand 1 | 10.93 | 1.99 | 4.34 |
| CCNE2 | 9134 | cyclin E2 | 7.22 | 3.41 | 3.56 |
| DTL | 51514 | denticleless E3 ubiquitin protein ligase homolog | 9.30 | 3.34 | 3.36 |
| GAL | 51083 | galanin/GMAP prepropeptide | 7.60 | 2.14 | 3.14 |
| RRM2 | 6241 | ribonucleotide reductase M2 | 5.16 | 3.68 | 3.09 |
| FAM111B | 374393 | family with sequence similarity 111, member B | 8.53 | 2.72 | 3.01 |
| HAS2 | 3037 | hyaluronan synthase 2 | 8.52 | 3.20 | 2.59 |
| WFDC1 | 58189 | WAP four-disulfide core domain 1 | 8.20 | 3.11 | 2.14 |
|
| |||||
| RCAN2 | 10231 | regulator of calcineurin 2 | 6.61 | −3.41 | −2.16 |
| SLC9A9 | 285195 | solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | 5.95 | −3.07 | −2.68 |
| CLEC3B | 7123 | C-type lectin domain family 3, member B | 5.42 | −3.52 | −2.79 |
| SECTM1 | 6398 | secreted and transmembrane 1 | 7.24 | −3.99 | −2.80 |
| KLF9 | 687 | kruppel-like factor 9 | 8.42 | −1.82 | −3.04 |
| FAXDC2 | 10826 | fatty acid hydroxylase domain containing 2 | 8.98 | −3.25 | −3.06 |
| AKR1C4 | 1109 | aldo-keto reductase family 1, member C4 | 6.65 | −2.91 | −3.10 |
| RUNX1T1 | 862 | runt-related transcription factor 1 | 7.80 | −1.76 | −3.13 |
| ADH1A | 124 | alcohol dehydrogenase 1A (class 1), alpha polypeptide | 7.78 | −4.16 | −3.13 |
| EFEMP1 | 2202 | EGF containing fibulin-like extracellular matrix protein 1 | 4.80 | −1.43 | −3.19 |
| AKR1C3 | 8644 | aldo-keto reductase family 1, member C3 | 7.84 | −3.41 | −3.35 |
| TNXB | 7148 | tenascin XB | 5.05 | −2.84 | −3.46 |
| SERPINF1 | 5176 | serpin peptidase inhibitor, clade F, member 1 | 6.13 | −1.46 | −3.52 |
| PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | 4.72 | −1.45 | −3.71 |
| PTGIS | 5740 | prostaglandin I2 (prostacyclin) synthase | 7.07 | −2.47 | −3.96 |
| MAN1C1 | 57134 | mannosidase, alpha, class 1C, member 1 | 7.25 | −3.59 | −4.58 |
| ADH1C | 126 | alcohol dehydrogenase 1C (class 1), gamma polypeptide | 8.14 | −5.48 | −5.56 |
a
Genes included have a raw p-value < 0.05 and FC > 3.0 or < −3.0 in either PAH or L-PAH Au NP samples. Entries that are not significant (p > 0.05) are italicized and those that are significant are in bold.
b
Average theoretical isoelectric points as calculated at http://isoelectric.ovh.org.