Table 2.
Methylationsites | Controls (n = 59) |
MDD (n = 61) |
Comparison (adj. for age and sex) |
MDD non-attempters (n = 39) |
MDD suicide attempters (n = 22) |
Comparison (adj. for age and sex) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | t-score | p | Adj. p | Mean | SD | Mean | SD | t-score | p | Adj. p | |
Fads1U | 2.79 | 0.39 | 2.75 | 0.31 | −0.50 | 0.620 | 0.620 | 2.76 | 0.37 | 2.71 | 0.16 | −0.85 | 0.396 | 0.554 |
Fads1CpG | 1.27 | 0.28 | 1.23 | 0.29 | −0.62 | 0.535 | 0.620 | 1.24 | 0.29 | 1.20 | 0.28 | −0.64 | 0.524 | 0.611 |
Fads1D | 1.21 | 0.41 | 0.96 | 0.89 | −2.01 | 0.046 | 0.107 | 1.02 | 0.73 | 0.84 | 1.14 | −0.94 | 0.349 | 0.554 |
Fads2U | 2.97 | 0.42 | 2.79 | 0.39 | −2.54 | 0.012 | 0.042 | 2.79 | 0.44 | 2.80 | 0.27 | −0.35 | 0.726 | 0.726 |
Fads2D | 4.21 | 0.19 | 4.27 | 0.16 | 1.56 | 0.121 | 0.212 | 4.24 | 0.18 | 4.31 | 0.08 | 0.97 | 0.335 | 0.554 |
ElovlU | 2.26 | 0.57 | 2.53 | 0.58 | 2.54 | 0.012 | 0.042 | 2.36 | 0.48 | 2.85 | 0.62 | 3.29 | 0.002 | 0.007 |
ElovlD | 1.88 | 0.26 | 1.84 | 0.25 | −0.64 | 0.526 | 0.620 | 1.91 | 0.26 | 1.70 | 0.19 | −3.74 | <0.001 | 0.003 |
“U” and “D” refer to upstream and downstream sites, respectively. MDD, major depressive disorder. Significant p-values after adjustment for multiple testing at the FDR = 0.05 level are shown in bold.