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. 2015 Apr 28;6:372. doi: 10.3389/fmicb.2015.00372

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Copyright © 2015 Piras, Maisetta, Sandreschi, Gazzarri, Bartoli, Grassi, Esin, Chiellini and Batoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytocompatibility evaluation of free TB (A) and of TB loaded into CS-NPs (B) in mouse embryo fibroblast cell line Balb 3T3/Clone A31. (A) Determination of free TB cytotoxicity. Results show that free TB displays an IC₅₀ value of ∼119 μg/ml after 24 h of incubation; (B) Comparison of cytotoxicity of different concentrations of free TB (116.5, 233, and 466 μg/ml) with the same amount loaded into CS-NPs (TB-CS-NPs), corresponding to TB-CS-NPs concentrations of 2.5, 5, and 10 mg/ml, respectively. Results show a statistically significant reduction of TB toxicity upon its loading into nanoparticles (^∗p < 0.05, Student’s t-test).