Table 2.
Locus | SNP | Model | n | Beta estimate | 95% CI | P value | Excluded from adjusted analysis | |
---|---|---|---|---|---|---|---|---|
LVEF | 9p21.3 | rs1333049 | Unadj. | 3,300 | 0.0044 | 0.0015 - 0.0074 | 3.6 × 10−3 | LVEF |
Adj.a | 2,212 | 0.0038 | 0.0005 - 0.0071 | 2.3 × 10−2 | ||||
10q11.21 | rs501120 | Unadj. | 3,300 | 0.0054 | 0.0012 - 0.0097 | 1.2 × 10−2 | ||
Adj.a | 2,216 | 0.0022 | −0.0025 - 0.0068 | 0.36 | ||||
15q22.33 | rs17228212 | Unadj. | 3,303 | −0.005 | −0.0084 - -0.0016 | 4.0 × 10−3 | ||
Adj.a | 2,218 | −0.0031 | −0.0069 - 0.0008 | 0.12 | ||||
log NT-proBNP (pmol/L) | 10q11.21 | rs501120 | Unadj. | 2,412 | −0.11 | −0.20 - -0.01 | 2.7 × 10−2 | log NT-proBNP (pmol/L) |
Adj.a | 2,216 | −0.064 | −0.14 - 0.02 | 0.12 | ||||
BMI (kg/m2) | 1q41 | rs17465637 | Unadj. | 3,298 | 0.35 | 0.11 - 0.60 | 4.8 × 10−3 | BMI (kg/m2) |
Adj.a | 2,220 | 0.3 | 0.03 - 0.58 | 2.9 × 10−2 | ||||
Serum creatinine (umol/L) | 10q11.21 | rs501120 | Unadj. | 3,300 | −2.01 | −3.80 - -0.21 | 2.8 × 10−2 | Serum creatinine (umol/L) |
Adj.a | 2,216 | −0.43 | −2.25 - 1.39 | 0.65 |
Abbreviations: SNP single nucleotide polymorphism, LVEF left ventricular ejection fraction, BMI body mass index, NT-proBNP N-terminal pro B-type natriuretic peptide. aAdjusted analyses were adjusted for age, sex, ejection fraction, NYHA class, systolic blood pressure, heart rate, body mass index, history of myocardial infarction, angina pectoris, diabetes mellitus, hypertension, stroke, intermittent claudication, aortic aneurysm, percutaneous coronary intervention, coronary artery bypass graft surgery, atrial fibrillation, implanted pacemaker, implanted cardiac defibrillator, smoking status, serum creatinine, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone, triglycerides, hsCRP and NT-proBNP [10]. As some covariates were also baseline variables or strongly associated to a baseline variable, covariates were excluded from analyses (see Additional file 3: Table S2). Results of all regression analyses for all SNPs are in Additional file 4: Table S3.