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. 2014 Dec 21;15:140. doi: 10.1186/s12881-014-0140-3

Table 2.

CAD loci ( P< 0.05) and heart failure disease markers in genetic sub-study of CORONA

Locus SNP Model n Beta estimate 95% CI P value Excluded from adjusted analysis
LVEF 9p21.3 rs1333049 Unadj. 3,300 0.0044 0.0015 - 0.0074 3.6 × 10−3 LVEF
Adj.a 2,212 0.0038 0.0005 - 0.0071 2.3 × 10−2
10q11.21 rs501120 Unadj. 3,300 0.0054 0.0012 - 0.0097 1.2 × 10−2
Adj.a 2,216 0.0022 −0.0025 - 0.0068 0.36
15q22.33 rs17228212 Unadj. 3,303 −0.005 −0.0084 - -0.0016 4.0 × 10−3
Adj.a 2,218 −0.0031 −0.0069 - 0.0008 0.12
log NT-proBNP (pmol/L) 10q11.21 rs501120 Unadj. 2,412 −0.11 −0.20 - -0.01 2.7 × 10−2 log NT-proBNP (pmol/L)
Adj.a 2,216 −0.064 −0.14 - 0.02 0.12
BMI (kg/m2) 1q41 rs17465637 Unadj. 3,298 0.35 0.11 - 0.60 4.8 × 10−3 BMI (kg/m2)
Adj.a 2,220 0.3 0.03 - 0.58 2.9 × 10−2
Serum creatinine (umol/L) 10q11.21 rs501120 Unadj. 3,300 −2.01 −3.80 - -0.21 2.8 × 10−2 Serum creatinine (umol/L)
Adj.a 2,216 −0.43 −2.25 - 1.39 0.65

Abbreviations: SNP single nucleotide polymorphism, LVEF left ventricular ejection fraction, BMI body mass index, NT-proBNP N-terminal pro B-type natriuretic peptide. aAdjusted analyses were adjusted for age, sex, ejection fraction, NYHA class, systolic blood pressure, heart rate, body mass index, history of myocardial infarction, angina pectoris, diabetes mellitus, hypertension, stroke, intermittent claudication, aortic aneurysm, percutaneous coronary intervention, coronary artery bypass graft surgery, atrial fibrillation, implanted pacemaker, implanted cardiac defibrillator, smoking status, serum creatinine, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone, triglycerides, hsCRP and NT-proBNP [10]. As some covariates were also baseline variables or strongly associated to a baseline variable, covariates were excluded from analyses (see Additional file 3: Table S2). Results of all regression analyses for all SNPs are in Additional file 4: Table S3.