Table 3.
CAD loci ( P < 0.05) and prognosis of ischemic heart failure in genetic sub-study of CORONA
| Locus | SNP | Model | n (total) | n (events) | Hazard ratio | 95% CI | P value | |
|---|---|---|---|---|---|---|---|---|
| All-cause Mortality | 1p13.3 | rs599839 | Unadj. | 3,300 | 527 | 0.86* | 0.74-1.00 | 4.99 × 10−2 |
| Adj.a | 2,218 | 341 | 0.74* | 0.61-0.90 | 2.5 × 10−3 | |||
| Mortality or WHF hospitalization | 10q11.21 | rs501120 | Unadj. | 3,300 | 1046 | 0.85* | 0.75-0.97 | 1.2 × 10−2 |
| Adj.a | 2,216 | 670 | 0.82* | 0.70-0.96 | 1.5 × 10−2 | |||
| Number of hospitalizations due to cardiovascular cause | 1p13.3 | rs599839 | Ordered Jonkeheere-Terpstra test | 9.3 × 10−3 | ||||
| Number of hospitalizations due to WHF | 10q11.21 | rs501120 | Ordered Jonkeheere-Terpstra test | 3.2x10−2 |
Abbreviations: SNP single nucleotide polymorphism, WHF worsening heart failure. aAdjusted analyses were adjusted for age, sex, ejection fraction, NYHA class, systolic blood pressure, heart rate, body mass index, history of myocardial infarction, angina pectoris, diabetes mellitus, hypertension, stroke, intermittent claudication, aortic aneurysm, percutaneous coronary intervention, coronary artery bypass graft surgery, atrial fibrillation, implanted pacemaker, implanted cardiac defibrillator, smoking status, serum creatinine, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone, triglycerides, hsCRP and NT-proBNP [10]. *directions were concordant with previous observations. [7] Regression data of all SNPs are presented in Additional file 5: Table S4.