Table 2.
Reference | Target | CAR construct | Method |
---|---|---|---|
(37) | CD19 | CD8α TM/CD3ζ | Retrovirus (mean 69%) |
CD8α TM/DAP10 | |||
CD8α TM/CD137/CD3ζ | |||
(40) | ErbB2 (HER-2) | CD28/CD3ζ | Retrovirus (mean 55%) |
(38) | CD19/GD2 | CD3ζ or 2B4 alone | Retrovirus (13–24%) |
2B4/CD3ζ | |||
CD8 TM/CD137/CD3ζ | |||
(39) | CD19 | CD137/CD3ζ | Transfection (mRNA) (mean 58%) |
(42) | NKG2D ligands | NKG2D/CD3ζ co-expressed with DAP10 | Retrovirus and mRNA transfection |
(41) | ErbB2 (HER-2) | CD3ζ alone | Retrovirus (40–50%) |
CD28/CD3ζ | |||
(33) | CD20 | CD137/CD3ζ | Transfection (mRNA) (50–95%) |