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. Author manuscript; available in PMC: 2015 Apr 28.
Published in final edited form as: Int J Hematol. 2014 Feb 22;99(4):393–406. doi: 10.1007/s12185-014-1534-x

Fig. 8.

Fig. 8

A model depicting the regulation of Nov/integrin αvβ3-mediated maintenance of LTR activity of HSCs that requires simultaneous stimulation by other cytokines. a TPO is not only involved in HSC maintenance, but it also induces αvβ3 integrin activation (a conformational change that increases its ligand affinity). b Nov associates with the integrin αvβ3, thereby enhancing the TPO- dependent maintenance of LTR activity that is mediated by β3 integrin outside-in signaling, c IFNγ is capable of impairing the LTR activity of HSCs independently of the TPO-dependent activation of the αvβ3 integrin. d The presence of exogenous Nov induces β3 integrin-mediated signaling by acting in concert with IFNγ rather than via TPO, resulting in further suppression of LTR activity