TABLE 1.

Parameter estimates, sample size, and estimated maximum DHEAS at the start of adulthood for models of DHEAS loss in human and chimpanzee females

Sample	N	Functional form	A (95% CI)	B (95% CI)	Max. DHEAS (μg/dL)
Chimpanzee Table S1 (Supporting Information)	65	y = A + B *ln(x)	180.73 (114.71, 250.44)	−33.86 (−55.20, −13.64)	89.04
Human Table S2 (Supporting Information)	698	y = eˆ(A + B × x)	6.24 (6.10, 6.35)	−0.03 (−0.03, −0.03)	281.46
Human standard	11	y = eˆ(A + B × x)	6.14 (6.02, 6.25)	−0.03 (−0.04, −0.03)	254.68

In all three models, x corresponds to years of age. The second row is a model fitted to data from Ravaglia et al. (1996), Sulcova et al. (1997), and Davison et al. (2005) detailed in Table S2 (Supporting Information). The third row describes a model fitted to 11 age-class means reported by Orentreich and colleagues (1984), which serves as check on the generality of our individual-based human model. To estimate maximum DHEAS (i.e., expected DHEAS concentration at the start of adulthood) reported in the last column, we evaluated our chimpanzee model at 15 years and the human models at 20 years.