Table 3. ORs From All 4 Pathologists (Blinded to C4d Results) for the 9 Variables With the Strongest Correlations With C4d-Positive Rejection in the UPMC Training Cohort and the Edinburgh University/BUMC Validation Cohorts.

Training Cohort	OR (CI)	P Value	Coefficient of Concordance*
Eosinophilic central venulitis	1.93 (1.25-2.96)	0.003	0.49
Portal vein endothelial cell hypertrophy	1.89 (1.19-2.99)	0.007	0.42
Eosinophilic portal venulitis	2.48 (1.24-4.96)	0.01	0.30
Central venulitis severity	2.26 (1.20-4.25)	0.02	0.33
L ymphocytic portal inflammation	0.59 (0.34-1.03)	0.06	0.40
Portal eosinophilia	1.43 (0.92-2.21)	0.11	0.40
L ymphocytic venulitis	0.78 (0.49-1.24)	0.30	0.32
Hepatocyte ballooning	1.14 (0.76-1.72)	0.53	0.44
Cholestasis	1.00 (0.71-1.42)	1.00	0.29

Validation Cohort	OR (CI)	P Value	Coefficient of Concordance*
Eosinophilic central venulitis	2.48 (1.37-4.49)	0.003	0.63
Portal vein endothelial cell hypertrophy	2.88 (1.83-4.55)	<0.001	0.62
Eosinophilic portal venulitis	3.05 (1.96-4.69)	<0.001	0.38
Central venulitis severity	2.44 (1.47-4.06)	<0.001	0.63
L ymphocytic portal inflammation	1.33 (0.79-2.22)	0.30	0.58
Portal eosinophilia	4.37 (2.54-7.51)	<0.001	0.61
L ymphocytic venulitis	1.65 (1.05-2.58)	0.03	0.42
Hepatocyte ballooning	2.00 (1.35-2.95)	<0.001	0.63
Cholestasis	2.09 (1.35-2.95)	<0.001	0.65

^*Kendall's coefficient of concordance displays the interobserver variability.