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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Oct 25;232(8):1415–1426. doi: 10.1007/s00213-014-3777-x

Figure 1.

Figure 1

Effect of bilateral intra-nucleus accumbens (NAc) shell infusions of ganaxolone (GAN) on 10% ethanol (10E) intake. A) Squares depict injector tip locations for mice (n = 15) used in the drinking studies for GAN infused into the NAc shell. B) A sample photomicrograph of a mouse that received a bilateral NAc shell infusion of GAN. C) Effect of NAc shell GAN on total 2-hour 10E intake, D) average bout frequency, and E) 10E licks split into 20-minute bins. F) Horizontal locomotor activity (cm) following a NAc shell infusion of 0 or 500 ng GAN across 20-minute bins, subtracting out cm moved on a baseline day. The inset depicts total 2-hour activity. Values represent mean ± SEM. + p ≤ 0.10, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 relative to 0 ng.