Table 2.

Effect of bilateral intra-nucleus accumbens shell ganaxolone (GAN) infusions on bout parameters for limited-access consumption of 10% ethanol (10E)

Dose GAN	0 ng	50 ng	100 ng	500 ng
2-hr 10E licks	541 ± 74	467 ± 67	334 ± 38	425 ± 72
22-hr water intake (ml)	3.3 ± 0.4	3.2 ± 0.4	3.0 ± 0.3	2.6 ± 0.5
Total fluid intake (ml)	3.9 ± 0.4	3.7 ± 0.5	3.4 ± 0.3	3.1 ± 0.5
Average bout size (licks)	98 ± 10	111 ± 11	103 ± 10	115 ± 14
Latency to first lick (min)	14.3 ± 4	19.2 ± 7	19.7 ± 9	9.1 ± 3
Latency to first bout (min)	20.8 ± 6	22.3 ± 7	20.6 ± 9	9.4 ± 3
First bout size (licks)	118 ± 20	120 ± 18	97 ± 10	116 ± 21
Termination of last bout (minutes)	104 ± 10	86 ± 10	84 ± 10	58 ± 12**

Values represent mean ± SEM for each dose. 0 ng represents the average of the pre and post vehicle infusion.

^**p ≤ 0.01 relative to 0 ng.