Table 3.

Effect of bilateral intra-nucleus accumbens shell THIP infusions on bout parameters for limited-access consumption of 10% ethanol (10E)

Dose THIP	0 ng	100 ng	500 ng
2-hr 10E licks	668 ± 70	587 ± 139	502 ± 161
22-hr water intake (ml)	3.2 ± 0.4	2.6 ± 0.5	3.8 ± 0.2
Total fluid intake (ml)	3.9 ± 0.3	3.1 ± 0.6	4.1 ± 0.3
Average bout size (licks)	98 ± 7	104 ± 15	105 ± 22
Latency to first lick (minutes)	24.8 ± 6	19.3 ± 8	8.7 ± 4
Latency to first bout (minutes)	25.0 ± 7	20.7 ± 8	11.5 ± 5
First bout size (licks)	93 ± 16	101 ± 23	71 ± 13
Termination of last bout (minutes)	115 ± 1	83 ± 7	102 ± 14

Values represent mean ± SEM for each dose. 0 ng represents the average of the pre and post vehicle infusion.