Skip to main content
. Author manuscript; available in PMC: 2015 May 6.
Published in final edited form as: Circ Cardiovasc Qual Outcomes. 2014 May 6;7(3):453–460. doi: 10.1161/CIRCOUTCOMES.113.000690

Table 3.

Estimated number-needed to treat and number-needed to harm with use of aspirin in MESA participants stratified by 10-year CHD risk and baseline CAC assuming an 18% reduction in CHD in both genders.

CHD risk < 10% No. of participants 5-yr CHD event rate Estimated5-yr NNT 5-yr estimated absolute increase in bleeding rate Estimated5-yr NNH
CAC = 0 1907 0.27% 2036 0.23% 442
CAC 1–99 633 0.97% 571
CAC ≥ 100 289 3.22% 173
CHD risk ≥ 10% No. of participants 5-yr CHD event rate Estimated5-yr NNT 5-yr estimated absolute increase in bleeding rate Estimated5-yr NNH
CAC = 0 454 0.69% 808 0.23% 442
CAC 1–99 460 3.82% 146
CAC ≥ 100 486 6.07% 92

Abbreviations: MESA – Multi-Ethnic Study of Atherosclerosis, CHD – Coronary Heart Disease, CAC – Coronary Artery Calcification, NNT – Number needed to treat, NNH – number needed to harm