Table 6.

Sensitivity Analysis: Estimated number-needed to treat and number-needed to harm with use of aspirin according to varying relative CHD risk reductions and varying absolute bleeding risk in MESA participants stratified by 10-year CHD risk and baseline CAC assuming.

MESA Participants	Estimated 5-yr NNT			Estimated 5-yr NNH
CHD risk < 10%	10% CHD risk reduction	20% CHD risk reduction	30% CHD risk reduction	0.5-fold bleeding risk	Standard bleeding risk	2-fold bleeding risk	4-fold bleeding risk
CAC=0 (n=1,907)	3,664	1,832	1,222	883	442	221	148
CAC ≥ 100 (n=289)	311	156	104
CHD risk ≥ 10%	10% CHD risk reduction	20% CHD risk reduction	30% CHD risk reduction	0.5-fold bleeding risk	Standard bleeding risk	2-fold bleeding risk	4-fold bleeding risk
CAC=0 (n=454)	1454	727	485	883	442	221	148
CAC ≥ 100(n=486)	165	83	55

Abbreviations: MESA – Multi-Ethnic Study of Atherosclerosis, CHD – Coronary Heart Disease, CAC – Coronary Artery Calcification, NNT – Number needed to treat, NNH – number needed to harm