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. Author manuscript; available in PMC: 2015 Apr 28.
Published in final edited form as: J Invest Dermatol. 2014 Mar;134(3):600–602. doi: 10.1038/jid.2013.443

Figure 1. Convergence of pathways in melanoma leads to NF-κB activation and glycolysis.

Figure 1

The major pathways in melanoma, Braf mutation, Nras mutation, and PHIP mutation all potentially involve a superoxide/Akt/NF-κB pathway (reactive oxygen–driven pathway) to result in glycolysis, NF-κB activation, and ulceration through angiopoietin-2 expression.