Table I.
6 weeks | 10 weeks | 12 weeks | ||||
---|---|---|---|---|---|---|
Control | MHC-miR130a | Control | MHC-miR130a | Control | MHC-miR130a | |
n | 5 | 5 | 5 | 5 | 5 | 3* |
PR (ms) | 33.1±2.9 | 34.7±3.2 | 35.2±0.7 | 40.8±0.6† | 33.0±1.2 | 44.0±2.5† |
QRS (ms) | 12.5±0.7 | 10.7±0.9 | 10.1±0.46 | 11.2±0.85 | 11.0±0.57 | 10.6±0.68 |
QT (ms) | 19.3±0.7 | 19.0±1.2 | 18.7±0.5 | 20.0±0.9 | 19.0±0.6 | 20.4±0.7 |
FS (%) | 35.8±0.2 | 32.0±2.8 | 31.8±1.1 | 32.3±1.7 | 35.5±2.2 | 24.7±1.7† |
LVIDd (mm) | 4.3±0.2 | 4.6±0.1 | 4.5±0.2 | 4.4±0.1 | 4.2±0.3 | 4.6±0.3 |
HR (bpm) | 534±98 | 515±105 | 512±113 | 519±96 | 514±89 | 459±113† |
2 of 5 mice in atrial arrhythmia, excluded from analysis of PR interval.
indicates p<0.01