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. Author manuscript; available in PMC: 2016 Apr 21.
Published in final edited form as: Immunity. 2015 Apr 14;42(4):654–664. doi: 10.1016/j.immuni.2015.03.006

Figure 5. Nlrp12−/− T cells are pathogenic.

Figure 5

. Purified CD4+CD45RBhi WT or Nlrp12−/− T cells were adoptively transferred into Rag1−/− mice. (A) Percent weight change over time. (B) Representative large intestine histology at 9 weeks post adoptive transfer of CD4+CD45RBhi T cells (original magnification ×20). (C) Combined colon histology scores. (D) Representative immunohistochemistry staining of T cells (anti-CD3), macrophages (anti-F4/80), neutrophils (anti-Gr-1), and cell death (TUNEL) in inflamed colon tissue (original magnification ×20). (E) Representative H&E ear sections (original magnification ×20). (F) Combined ear histology scores. Each point represents an individual mouse and the line represents the mean ± s.e.m. Data are representative of four independent experiments with 3-7 mice per genotype. *P < 0.05, **P < 0.01; Student's t-test. See also Figure S6.