Table 4.
All studies reporting the percentage of in-hospital ADR occurrence among patients–studies in children or the elderly
| References | Year | Country | Study design | Study length | Study setting | Sample size | ADR occurrence rate (%) | Detection method | ADR definition | Causality | Fatal ADRs (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Weiss et al. [46] | 1999–2000 | Germany | Single-center | 8 months | Pediatric ward; university hospital | 214 | 21.5 | ICR | ADR (WHO) | NR | 0 |
| Jonville-Béra et al. [30] | 1998 | France | Single-center | 1 week | Pediatric hospital | 256 | 2.3 | ICR | ADR | NR | 0 |
| Buajordet et al. [31] | 1996 | Norway | Single-center | 5 months | University hospital; pediatric department | 880 | 11.9 | VR + ICR | ADR (WHO) | NR | NR |
| Haffner et al. [32] | 2001 | Germany | Single-center | 13 weeks | Pediatric teaching hospital | 690 | 10.3 | ICR | ADR (WHO) | 71.3 % Probable or definite | NR |
| Rashed et al. [35] | 2008–2009 | UK + Germany | Single-center | 3 months | Pediatric ward | 305 (UK) | 18.6 (both countries combined) | ICR | ADR (WHO) | NR | NR |
| 373 (Germany) | |||||||||||
| Oehme et al. [47] | 2008 | Germany | Single-center | 3 months | Department of pediatric medicine; university hospital | 517 | 10.6 | ICR | ADR (WHO) | NR | 0 % |
| Corsonello et al. [48] | 2007 | Italy | Multicenter (11) | 3 months | 11 Acute care wards | 506 | 11.5 | ICR | ADR (WHO) | NR | NR |
| Egger et al. [49] | 2001–2002 | Germany | Single-center | 4 months | Geriatic department | 163 | 60.7 | ICR | ADR (WHO) | 53.6 % Possible, 45.8 % probable, 0.7 % definite | NR |
| Conforti et al. [39] | 2009 | Italy | Single-center | 6 months | Geriatric ward | 909 | 28.2 | ICR | ADR (WHO) | NR | NR |
The total number of patients admitted during the study period is reported (under sample size). ADR occurrence was calculated by dividing the number of patients who experienced at least one ADR, or the number of admissions during which at least one ADR occurred, by the total number of patients or hospital admissions. The ADR definition that was reported is stated, including whether the WHO definition was used in the study
ADR adverse drug reaction, WHO World Health Organization, ICR intensive chart review, VR voluntary reporting, NR not reported