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. Author manuscript; available in PMC: 2016 Feb 25.
Published in final edited form as: Adv Mater. 2015 Jan 12;27(8):1356–1362. doi: 10.1002/adma.201404993

Figure 3.

Figure 3

Patterning of biochemical ligands alters cell attachment and morphology. (A) Photomask (white areas indicate areas permitting transmittance of UV light) used to covalently attach thiolated RGD to the nanofibrous scaffold (PBL – Polymeric Biomaterials Lab). (B–D) 3T3 fibroblasts adhere to the RGD pattern with high fidelity. Scale bars: (B,D) 100 μm, (C) 500 μm. Quantification of the number of cells per area (E), aspect ratio (F), and cell area (G) shows differences in cell adhesion, elongation, and morphology between nanofiber regions patterned with RGD and nanofiber regions without RGD. (p<0.001)