Table 2. LINE-1 methylation status by demographic and clinicopathologic features.
| Variable | N | LINE-1 methylation % (SD) | p-value |
|---|---|---|---|
| Age <65 y/o | 73 | 64.6 (6.4) | 0.019 |
| ≧65y/o | 56 | 61.7 (7.6) | |
| Sex, male | 81 | 63.0 (6.6) | 0.562 |
| Female | 48 | 63.8 (7.8) | |
| Tumor size≧5cm | 48 | 62.2 (7.7) | 0.156 |
| <5cm | 81 | 63.9 (6.6) | |
| Histology a | |||
| WD | 6 | 64.4 (4.3) | 0.481 |
| MD | 105 | 63.6 (6.6) | |
| PD | 18 | 61.5 (9.8) | |
| T stage | |||
| T1 | 4 | 68.2 (3.5) | 0.195 |
| T2 | 12 | 64.7 (6.8) | |
| T3 | 89 | 62.5 (6.3) | |
| T4 | 24 | 64.8 (9.6) | |
| N stage | |||
| N1 | 87 | 63.8 (6.3) | 0.238 |
| N2 | 42 | 62.3 (8.5) | |
| Perineural invasion | |||
| No | 86 | 63 (7.1) | 0.499 |
| Yes | 43 | 63.9 (6.9) | |
| Vascular invasion | |||
| No | 83 | 63.4 (6.6) | 0.769 |
| Yes | 46 | 63.1(7.8) | |
| Tumor location b | |||
| Right | 40 | 65 (6.3) | 0.070 |
| Left | 89 | 62.6 (7.3) |
a WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated.
b Tumor location is divided according to sites to the right or left of the splenic flexure.