Fig. 4.

Effect of one-leg knee extension exercise on sphingolipid content in skeletal muscle. Subjects performed three consecutive periods of exercise separated by 30 min of rest. First subjects exercised with one leg for 30 min at 25 % of maximal workload (W _max), then with the other leg for 120 min at 55 % of W _max, and finally again with the first leg for 30 min at 85 % of W _max. The biopsies of vastus lateralis muscle from the working leg were taken at indicated time points (n = 10). The results are mean ± SEM. *p < 0.05 vs. the value before the respective exercise. S1P sphingosine-1-phosphate