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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Nat Rev Nephrol. 2015 Feb 3;11(5):264–276. doi: 10.1038/nrneph.2015.3

Figure 4.

Figure 4

Common mechanisms in kidney ageing and progressive kidney injury. Features of kidney ageing include tubular loss, glomerulosclerosis, microvascular rarefaction and deposition of interstitial collagen. The number of senescent and G2/M arrested cells present in the ageing kidney also progressively increases. All the above cellular changes are also seen in progressive renal disease in younger patients following acute renal insults. These shared features suggest that progressive chronic kidney disease is functionally equivalent to accelerated ageing of the kidney. Abbreviation: AKI, acute kidney injury.