Fig. 6.
Olanzapine binding site. (A) Predicted olanzapine (OLZ) binding in GlcPSe, corresponding to site 2 from Fig. 2; R129 and N136 are in olanzapine binding site. (B) Outward-facing conformation of GlcPSe; R129 and E362 form a salt bridge shown as a yellow line, pointed by the red arrow. (C) Inward-facing conformation of GlcPSe with olanzapine interacting with R129 and N136. Olanzapine prevents the formation of the salt bridge between R129 and E362 that stabilizes the outward-facing conformation, thus locking the transporter in the inward-facing conformation. (D) Cartoon diagram of olanzapine binding site showing presumed interactions with N136 and R129. Figures were drawn using Molscript [34] and raster3D [35].