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. 2015 Apr 29;35(17):6752–6769. doi: 10.1523/JNEUROSCI.2663-14.2015

Figure 7.

Figure 7.

Membrane hyperpolarization rescues repetitive firing in adult Fgf14−/− Purkinje neurons. A–D, Representative recordings from WT and Fgf14−/− Purkinje neurons obtained using the protocols described in the legend to Figure 5. Removal of the (500 pA) hyperpolarizing current resulted in repetitive firing in most (24 of 32) of the WT neurons (A) and in 11 of the 23 Fgf14−/− neurons (B). Depolarizing (1000 pA) current injections, presented from hyperpolarized membrane potentials, resulted in repetitive firing in most (29 of 32) WT (C) and (21 of 23) Fgf14−/− (D) Purkinje neurons. E, Mean ± SEM firing frequencies in WT and Fgf14−/− Purkinje neurons in response to prolonged (250 ms) depolarizing current injections of varying amplitudes. Firing rates increased as a function of the amplitudes of the depolarizing current injections and were indistinguishable (two-way ANOVA) in WT (n = 32) and Fgf14−/− (n = 23) Purkinje neurons.