Skip to main content
. 2015 Apr 29;35(17):6770–6785. doi: 10.1523/JNEUROSCI.4926-14.2015

Figure 4.

Figure 4.

Anti-ganglioside Abs induce axonal degeneration in sciatic nerves with L5SNT. A, B, Micrographs showing significantly more axonal degeneration in GT1b–2b treated-nerve (B) compared with control-Ab treated-sciatic nerve (A). Scale bar, 20 μm. C, D, Morphometry showing that there was a significant decrease in the number of MFs at both the sciatic (C) and tibial (D) levels in GT1b–2b treated-animals on postsurgical days 7 and 14. E, Behavioral studies show that mice treated with GT1b–2b or control Abs developed mechanical allodynia 1 d after L5SNT and the allodynia in control Ab-treated mice persisted throughout the study, whereas there was significant reversal of allodynia in mice treated with GT1b–2b beginning at postsurgical day 8. F, Significant MF loss in sural nerves was found in GT1b–2b treated-animals on postsurgical days 7 and 14 compared with the control Ab treated-group. G, Morphometry showing that no significant MF loss in sciatic nerve was found in animals treated with GD1a/GT1b–2b, GD1a–2b, and GM1–2b mAbs on postsurgical day 14. n = 12. *p < 0.05. Scale bar, 20 μm. SN, Sciatic nerve; TN, tibial nerve.