Figure 5.

Anti-ganglioside Abs-induced nerve injury requires the formation of ICs. A, B, Micrographs showing MF in sciatic nerves of B4galnt1-null mice treated with control (A) and GT1b–2b (B) mAb. Nerve fiber degeneration because of L5SNT can be appreciated in the nerves of both treatment groups. C, D, Morphometric (C) and electrophysiological (D) analyses indicate that neither the numbers of MF at the sciatic nerve (SN) and tibial nerve (TN) levels nor CMAP amplitudes were altered by GT1b–2b treatment. n = 6. Scale bar, 20 μm.