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. 2015 Apr 29;35(17):6871–6880. doi: 10.1523/JNEUROSCI.4539-14.2015

Figure 1.

Figure 1.

IH-1 increased inflammatory gene expression in the cervical spinal cord. A, Homogenate samples isolated from the cervical spinal cord containing neurons, astrocytes, and microglia showed an initial increase in IL-6 (1.5 ± 0.2-fold change) immediately after 8 h of intermittent hypoxia and an increase in iNOS (2.4 ± 0.4-fold change) mRNA after IH-1 that were significantly greater than those in normoxia control samples. B, In isolated microglia, IL-1β mRNA increased immediately after 8 h IH (2.4 ± 0.2-fold change) and IH-1 (2.4 ± 0.2-fold change) compared to normoxic controls. No other inflammatory genes in the homogenate or microglia samples changed significantly at either time point after IH. **p < 0.01; ***p < 0.001 (significant difference from normoxic controls); #p < 0.05; ##p < 0.01 (significant difference from IH-1, one-way ANOVA, Fisher LSD post-test).