Table 3.
Physiological parameters for Sprague Dawley 211 rats during electrophysiological experiments after IH-1, normoxia, or time control and spinal inhibition of p38 MAPK (SB 202190, 1 mM)
| Time | Treatment group | Temperature | PaO2 | PaCO2 | pH | MAP |
|---|---|---|---|---|---|---|
| Baseline | Time control, veh | 37.6 ± 0.2 | 331 ± 9**** | 45 ± 1 | 7.364 ± 0.005 | 124 ± 2 |
| Nx, veh | 37.3 ± 0.1 | 310 ± 12 | 45 ± 1 | 7.355 ± 0.011 | 117 ± 5 | |
| IH-1, veh | 37.3 ± 0.3 | 311 ± 9 | 45 ± 1 | 7.337 ± 0.013 | 128 ± 5 | |
| Nx, p38 | 37.5 ± 0.1 | 328 ± 3 | 44 ± 1 | 7.367 ± 0.007### | 124 ± 6 | |
| IH-1, p38 | 37.2 ± 0.1 | 322 ± 10 | 44 ± 1 | 7.346 ± 0.007 | 125 ± 7 | |
| Time control, p38 | 37.3 ± 0.3 | 312 ± 9.5 | 45 ± 1 | 7.324 ± 0.0183 | 134 ± 3**** | |
| Hx | Time control, veh | 37.6 ± 0.1 | 328 ± 5# | 45 ± 1 | 7.361 ± 0.005 | 123 ± 3# |
| Nx, veh | 37.3 ± 0.1 | 38 ± 1* | 45 ± 1 | 7.341 ± 0.014 | 62 ± 7* | |
| IH-1, veh | 37.2 ± 0.3 | 40 ± 1* | 46 ± 1 | 7.322 ± 0.014## | 71 ± 7* | |
| Nx, p38 | 37.4 ± 0.1 | 35 ± 1* | 44 ± 2 | 7.339 ± 0.012**,## | 63 ± 6* | |
| IH-1, p38 | 37.2 ± 0.1 | 38 ± 1* | 45 ± 1 | 7.332 ± 0.011 | 67 ± 5* | |
| Time control, p38 | 37.2 ± 0.2 | 311 ± 10# | 45 ± 1 | 7.329 ± 0.014 | 134 ± 32 | |
| 60 min | Time control, veh | 37.6 ± 0.1 | 315 ± 10 | 44 ± 1 | 7.381 ± 0.008**,*** | 118 ± 3 |
| Nx, veh | 37.5 ± 0.1 | 297 ± 11 | 45 ± 1 | 7.359 ± 0.009 | 107 ± 5 | |
| IH-1, veh | 37.5 ± 0.2 | 305 ± 11 | 45 ± 1 | 7.339 ± 0.017***,## | 115 ± 5 | |
| Nx, p38 | 37.6 ± 0.1 | 305 ± 5** | 45 ± 1 | 7.362 ± 0.010*** | 119 ± 5 | |
| IH-1, p38 | 37.5 ± 0.1 | 299 ± 8** | 44 ± 1 | 7.348 ± 0.005*** | 114 ± 4** | |
| Time control, p38 | 37.2 ± 0.2 | 308 ± 12 | 45 ± 1 | 7.343 ± 0.014## | 121 ± 5* | |
| 90 min | Time control, veh | 37.6 ± 0.1 | 327 ± 3**** | 44 ± 1 | 7.388 ± 0.007**,*** | 117 ± 6 |
| Nx, veh | 37.5 ± 0.1 | 295 ± 9 | 45 ± 1 | 7.361 ± 0.009*** | 108 ± 4 | |
| IH-1, veh | 37.3 ± 0.2 | 300 ± 10 | 46 ± 2 | 7.341 ± 0.024*** | 113 ± 5 | |
| Nx, p38 | 37.5 ± 0.1 | 308 ± 4**,## | 44 ± 2 | 7.367 ± 0.011*** | 116 ± 6** | |
| IH-1, p38 | 37.5 ± 0.1 | 303 ± 7 | 45 ± 1 | 7.359 ± 0.006*** | 109 ± 4** | |
| Time control, p38 | 37.4 ± 0.2 | 307 ± 11 | 45 ± 1 | 7.376 ± 0.011**,*** | 123 ± 4**** |
*p < 0.001 (difference from all other time points within treatment group);
**p < 0.05 (difference from baseline within treatment group);
***p < 0.05 (difference from Hx within treatment group);
****p < 0.05 difference from Nx, veh within time point);
#p < 0.001 (difference from treatment groups receiving AIH within Hx);
##p < 0.01 (difference from time control, veh within time point);
###p < 0.05 (difference from Nx, p38 and Nx, veh). Hx, Hypoxia; MAP, mean arterial pressure.