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. 2015 Apr 29;35(17):6893–6902. doi: 10.1523/JNEUROSCI.4002-14.2015

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Copyright © 2015 the authors 0270-6474/15/356893-10$15.00/0

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Figure 2. — NO maintains long term depression in young 3xTg-AD mice. A–C, Graph shows averaged time course of LTD from NonTg and 3xTg-AD mice in aCSF (A), l-NAME (B), and SNAP (C). Insets, Representative baseline traces before (1) and after (2) LFS from NonTg (black) and 3xTg-AD (gray) mice. D, Bar graph shows percentage change in post-LFS responses relative to baseline 0–2 min after LFS (STD), 15–20 min after LFS (E-LTD), and 50–60 min after LFS (L-LTD). The arrow denotes the time at which the LFS (900 pulses at 1 Hz) was administered; *p < 0.05 indicates significantly different from NonTg; **p < 0.05 indicates significantly different from control aCSF-treated slices.